What is the difference between finasteride and dutasteride?
Finasteride inhibits only type 2 5-alpha reductase, partially reducing DHT, while dutasteride inhibits both type 1 and type 2, resulting in a stronger DHT reduction effect. Dutasteride is more effective at suppressing hair loss, but may also have a higher potential for hormonal side effects. The appropriate choice depends on hair loss stage, age, and side effect history.
Worried about side effects. Do I really need to take hair loss medication?
Side effects such as sexual dysfunction from finasteride and dutasteride are reported in about 1–5% of clinical cases, and are usually reversible after stopping the medication. If side effects are a concern, hair loss progression can also be slowed using minimized medication strategies such as topical minoxidil, alfatradiol, and follicle-strengthening injections. Recently, topical finasteride has also been introduced as an alternative. It is important to determine the appropriate treatment intensity based on follicle condition and progression speed with a specialist.
Do I have to take hair loss medication forever?
DHT inhibitors often require long-term use because stopping them leads to a rise in DHT levels and recurrence of hair loss. However, duration and dosage can be adjusted depending on progression and side effects. If long-term medication is burdensome, a combined approach with injections or procedures and reduced dosage can be discussed with a specialist.
What is the difference between oral minoxidil and topical minoxidil?
Oral minoxidil is systemically absorbed and improves overall scalp blood flow, and is increasingly used at low doses due to its effectiveness. Typical starting doses are 1.25–2.5 mg for women and 2.5–5 mg for men. Topical minoxidil is applied directly to the scalp, producing localized vasodilation with a lower risk of systemic side effects. Rather than combining both immediately, it is common to start with one and adjust based on follicle condition and side effects.
Can women take finasteride?
Finasteride and dutasteride are generally not recommended for women of reproductive age due to the risk of fetal abnormalities. For female hair loss, alternatives such as spironolactone (androgen receptor blocker), topical minoxidil, and alfatradiol are used. Spironolactone also requires caution and contraception in women of reproductive age. Since female hair loss is often multifactorial, evaluation of hormones, thyroid function, and anemia is necessary before selecting a treatment plan.
If I stop minoxidil, will my hair fall out more?
If the hair loss was temporary, stopping minoxidil will not cause additional shedding. However, in ongoing hair loss conditions (such as androgenetic alopecia), stopping minoxidil leads to a gradual loss of the maintained effect, and hair that was being sustained may slowly shed. It does not make hair loss worse than before starting the treatment.
What is the difference between hair loss supplements and hair loss medications?
Nutritional components such as biotin, amino acids, and keratin support hair structure and follicle metabolism, but have limited ability to directly stop ongoing hair loss. Hair loss medications (such as finasteride and minoxidil) directly target causes like DHT and blood flow. Nutrients are most effective as supportive therapy when used alongside medications and injections to support the follicle environment.
What is the cost of hair loss medications?
The cost varies depending on the type and combination of prescribed medications, treatment duration, and whether combined therapies are included. In general, prescription medications such as finasteride and dutasteride are not covered by insurance in many cases, so costs may apply. Exact prescriptions and pricing are provided after an in-person consultation.
Treatment Methods
Treatment Based on the Cause of Hair Loss Starts with the Right Medication Selection Hair Loss Medication (Oral Drugs & Topical Agents)
You must first identify which medication is ‘suitable for your current follicle condition.’
If you have the following hair loss concerns,you may consider Prescription Hair Loss Medication.
There is a family history of hair loss, and hair is starting to become finer.
You want to prevent progression while still in the early stage where follicles are still alive.
You want to improve results while undergoing injection treatments in combination.
You are currently taking hair loss medication but the effect is unclear or side effects are a concern.
What are hair loss medications?
Hair loss medications are broadly divided into oral medications (taken by mouth) and topical treatments (applied products such as solutions or shampoos).
Oral medications act systemically through mechanisms such as DHT inhibition, vasodilation, antioxidant effects, and nutrient supply to hair. Topical treatments improve the local scalp environment or promote blood flow. Combining both types according to the cause and stage of hair loss is generally the most effective strategy.
DHT Suppression
Improved Blood Circulation
Scalp Environment Improvement
HairON Clinic designs personalized medication combinations
and dosages based on follicle condition diagnosis.
and dosages based on follicle condition diagnosis.
Oral medications for hair loss treatment
Oral hair loss drugs work through multiple mechanisms such as DHT inhibition, vasodilation, antioxidant effects, and nutrient support for hair.
Their effect is enhanced when combined according to the underlying cause rather than used as a single ingredient.
DHT Inhibitor ClassKey medications that slow hair loss progression
Finasteride and Dutasteride are 5-alpha reductase inhibitors that reduce DHT production and are first-line treatments for androgenetic (genetic) hair loss. Finasteride inhibits type 2 5-alpha reductase, while Dutasteride inhibits both type 1 and type 2. Since stopping the medication can cause DHT levels to rise again and hair loss to resume, long-term use is common, with dosage adjusted based on side effects.
Finasteride
5-alpha reductase type 2 inhibition
Reduces DHT, slows male pattern hair loss progression
Dutasteride
5-alpha reductase type 1 and 2 inhibition
Stronger DHT reduction, suppresses follicular miniaturization
Oral MinoxidilExtends the hair growth phase by improving blood flow
Oral minoxidil increases scalp blood circulation and extends the hair growth phase through vasodilation and potassium channel activation. Compared to topical minoxidil, it has higher systemic absorption, allowing effectiveness even at low doses. When combined with DHT inhibitors, it provides a complementary effect. Side effects such as increased body hair and orthostatic hypotension may occur, so treatment typically starts with low doses.
Oral Minoxidil
Vasodilation, K⁺ channel activation
Increased scalp blood flow, prolonged growth phase, increased hair thickness
Spironolactone
Androgen inhibition for female hair loss
Spironolactone blocks androgen receptors, suppressing the action of DHT and is used for female pattern hair loss. As with finasteride and dutasteride, it is contraindicated during pregnancy, and contraception is required for women of reproductive age. Blood pressure drops and electrolyte imbalance may occur, so regular blood tests and medical monitoring are necessary.
Spironolactone
Androgen receptor blockade
Suppresses DHT activity, slows female pattern hair loss progression
Hair Nutritional Components
Supporting the follicle environment from within
Supporting the follicle environment from within
Biotin, pantothenic acid, amino acids, and keratin support keratin synthesis, the main structural protein of hair, and support energy metabolism in follicle cells. Ginkgo improves microvascular blood flow in the scalp, and glutathione reduces oxidative stress in follicles. Nutrients alone have limited ability to stop ongoing hair loss, but they play a supportive role when combined with DHT inhibitors and circulation-improving medications.
Biotin
Keratin supports synthesis
Hair structure formation and strength maintenance
Pantothenic Acid (Vitamin B5)
Cell energy metabolism (CoA)
Supports follicle activity and sebum regulation
Keratin
Hair structural protein
Maintains hair strength and elasticity
Amino Acids (Cystine, etc.)
Raw material for keratin synthesis
Promotes hair growth and protein synthesis
Ginkgo
Improves microcirculation
Enhances scalp blood flow and antioxidant effects
Probiotics
Improves gut environment
Enhances nutrient absorption and reduces inflammation
Glutathione
Strong antioxidant effect
Reduces oxidative stress in hair follicles
Topical Treatments for Hair Loss
Topical hair loss medications act directly on the scalp to stimulate blood flow,
inhibit DHT production, and reduce inflammation.
inhibit DHT production, and reduce inflammation.
두피에 직접 작용하는 혈류 개선
외용 미녹시딜은 두피에 직접 도포해 모세혈관을 확장하고 모낭 성장기를 연장하는 외용제입니다. 2%, 5% 농도가 있으며 남녀 모두 사용 가능하고, 경구약 복용이 부담스러운 경우의 대안 또는 병행 선택지로 활용됩니다. 도포 부위 자극, 체모 증가, 중단 시 일시적 탈모 증가(휴지기 전환) 등의 반응이 나타날 수 있습니다.
Minoxidil (Topical)
Scalp vasodilation
Prolongs growth phase, increases hair density
두피 국소 DHT 억제
두피에 국소 적용해 5알파-환원효소를 억제하고 DHT 생성을 줄이는 외용제로, 경구 DHT 억제제의 전신 부작용이 걱정될 때 대안으로 활용됩니다. 경구 피나스테리드·두타스테리드에 비해 전신 흡수가 적고, 여성 탈모에도 사용 가능합니다. 단독보다 경구약·미녹시딜과 병행할 때 효과가 안정적으로 유지됩니다.
El Cranell (Alfatradiol)
5-alpha reductase inhibition
Reduces DHT production, slows hair loss progression
Prostome A
Tretinoin-based topical treatment
Improves scalp environment and enhances absorption of topical agents
두피 염증 환경 개선
토코나졸 성분의 니조랄 샴푸는 지루성 두피염 원인균을 억제하고 두피 염증을 낮춰 탈모 진행 환경을 개선합니다. 탈모 치료제는 아니지만, 두피 염증이 동반된 탈모에서 보조 치료로 폭넓게 활용됩니다. 주 2~3회 사용이 일반적이며, 과도한 사용은 두피 건조를 유발할 수 있습니다.
Nizoral Shampoo (Ketoconazole)
Antifungal and anti-inflammatory
Improves seborrheic scalp condition and reduces hair loss progression
Treatment design is key, so pre-treatment diagnosis is important.
Treatment plans must be designed based on treatment goals, follicle condition, gender, comorbidities, and side effect history.
Book DiagnosisHairON Clinic determines medication-only or combined strategies with injections and procedures through precise scalp and follicle diagnosis.
Frequently Asked Questions
Hair Loss Research Center
Hair Loss Research CenterUltimately, the Key to Hair Loss is Diagnosing the Underlying Cause.
HairON Clinic approaches hair loss through a consistent process of diagnosis, treatment, and ongoing care. Every treatment begins with a comprehensive evaluation to identify the underlying cause.
Book DiagnosisHairON ClinicHours of Operation
- Weekdays (Mon–Fri)
- Saturday
- Lunch Break
- Phone Consultation
- 3F, Hongwoo Building, 373 Gangnam-daero, Seocho-gu, Seoul, South Korea
Insights » Hair Loss Treatment by Dr. Hyunggon Son
A First Visit Story: Female Hair Loss in Her 40s at HairON Clinic
Hair loss in women in their 40s may not be simply a sign of aging. If you’re concerned about thinning hair or reduced volume, explore the causes and management options through a first visit to Hairon Clinic.


